S M McLachlan Selected Research

Thyroid-Stimulating Immunoglobulins

4/2010	Immunoglobulin heavy chain variable region genes contribute to the induction of thyroid-stimulating antibodies in recombinant inbred mice.
12/2004	TSH receptor-adenovirus-induced Graves' hyperthyroidism is attenuated in both interferon-gamma and interleukin-4 knockout mice; implications for the Th1/Th2 paradigm.
11/2004	Susceptibility rather than resistance to hyperthyroidism is dominant in a thyrotropin receptor adenovirus-induced animal model of Graves' disease as revealed by BALB/c-C57BL/6 hybrid mice.
3/2004	Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease.
8/2001	Naked TSH receptor DNA vaccination: A TH1 T cell response in which interferon-gamma production, rather than antibody, dominates the immune response in mice.
5/2001	A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

S M McLachlan Research Topics

Disease

9	Graves Disease (Basedow Disease) 04/2010 - 08/2000
8	Hyperthyroidism 01/2017 - 08/2001
5	Autoimmune Diseases (Autoimmune Disease) 01/2017 - 01/2000
5	Thyroiditis 01/2017 - 01/2001
2	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 01/2019 - 01/2001
1	Genetic Predisposition to Disease (Genetic Predisposition) 04/2010
1	Lymphoma (Lymphomas) 12/2004
1	Schistosomiasis mansoni 12/2004
1	Goiter 02/2003
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2000
1	Thyroid Diseases (Thyroid Disease) 01/2000
1	Hypothyroidism 01/2000

Drug/Important Bio-Agent (IBA)

10	Thyrotropin Receptors (Thyrotropin Receptor)IBA 04/2010 - 01/2000
9	AutoantibodiesIBA 01/2017 - 01/2000
6	AntibodiesIBA 01/2019 - 11/2000
6	Thyroid-Stimulating ImmunoglobulinsIBA 04/2010 - 05/2001
5	Iodide Peroxidase (Deiodinase)IBA 01/2019 - 01/2000
4	AutoantigensIBA 01/2017 - 02/2003
3	Thyroglobulin FDA Link 01/2019 - 01/2000
3	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2017 - 02/2003
3	CytokinesIBA 12/2004 - 10/2000
3	Immunoglobulin G (IgG)IBA 11/2004 - 01/2000
2	Histocompatibility Antigens Class IIIBA 06/2015 - 08/2001
2	Interferon-gamma (Interferon, gamma)IBA 12/2004 - 03/2004
2	Interleukin-4 (Interleukin 4)IBA 12/2004 - 10/2000
2	Amino Acids FDA Link 03/2004 - 05/2001
2	AntigensIBA 05/2001 - 03/2001
1	IodidesIBA 06/2015
1	Dietary SodiumIBA 06/2015
1	difluprednate FDA Link 04/2010
1	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA 04/2010
1	alpha-galactosylceramideIBA 12/2004
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 03/2004
1	Peptides (Polypeptides)IBA 03/2004
1	Proteins (Proteins, Gene)FDA Link 03/2004
1	EpitopesIBA 06/2003
1	Immunodominant EpitopesIBA 06/2003
1	beta-Galactosidase (Lactaid)IBA 02/2003
1	Thyroxine (Levothyroxine)FDA LinkGeneric 02/2003
1	DNA (Deoxyribonucleic Acid)IBA 08/2001
1	laminin gamma 1IBA 05/2001
1	Epidermal Growth Factor (EGF)IBA 05/2001
1	DisulfidesIBA 05/2001
1	Biological ProductsIBA 05/2001
1	Laminin (Merosin)IBA 05/2001
1	Cysteine (L-Cysteine)FDA Link 05/2001
1	Interleukin-10 (Interleukin 10)IBA 10/2000
1	Monoclonal AntibodiesIBA 01/2000

Therapy/Procedure

2	Injections 03/2004 - 02/2003
1	Subcutaneous Injections 02/2003
1	Therapeutics 01/2000